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EurekAlert : declared in Study shows how HIV breaches macrophage defenses, could be step towards cure

according to Lead author of the EMBO Journal study, Dr Petra Mlcochova (UCL Infection & Immunity) said: “Other viruses can disable SAMHD1, but HIV cannot.
The researchers say that macrophages can be an important reservoir of HIV Infection that lingers away from the reach of existing treatments.
Once a macrophage is infected, it will continually produce the HIV virus, so cutting off that point of Infection within the body could be an important step towards safeguarding the entire immune system.
HDAC inhibitors may be particularly helpful as they’re already known to reactivate latent HIV cells, thus making the virus vulnerable to the body’s defences, especially if supported by anti-retroviral therapy.
They discovered a treatment that can maintain macrophage defences which could be a key part of the puzzle of reaching a complete cure for HIV/AIDS.

referring to

New method protects macrophage defenses to treat HIV

Study shows how HIV breaches macrophage defenses, could be step towards cure

Jan. 25 (UPI) — New research by the University College London has discovered the method the HIV virus uses to infect macrophages, which could potentially lead to a cure for HIV.
Researchers also learned how to prevent HIV from infecting macrophages by treating the cells with HDAC inhibitors.
Macrophages have an antiviral protein called SAMHD1, which can prevent HIV from replicating.
“Our work explains how HIV can still infect macrophages, which are disabling SAMHD1 by themselves.”
However, when SAMHD1 is turned off, the virus is able to infect macrophages by penetrating its protective protein barrier.
Study shows how HIV breaches macrophage defenses, could be step towards cure

Lead author of the EMBO Journal study, Dr Petra Mlcochova (UCL Infection & Immunity) said: “Other viruses can disable SAMHD1, but HIV cannot.
The researchers say that macrophages can be an important reservoir of HIV Infection that lingers away from the reach of existing treatments.
HDAC inhibitors may be particularly helpful as they’re already known to reactivate latent HIV cells, thus making the virus vulnerable to the body’s defences, especially if supported by anti-retroviral therapy.
A team led by UCL researchers identified how HIV is able to infect macrophages, a type of white blood cell, despite the presence of a protective protein.
They discovered a treatment that can maintain macrophage defences which could be a key part of the puzzle of reaching a complete cure for HIV/AIDS.

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