Home / Health care / Gene therapy restores hearing in deaf mice, down to a whisper: Improved delivery vector better penetrates the inner ear, also restores balance in a mouse model of Usher syndrome — ScienceDaily stat : sciencedaily
alibaba.com, cpa campaign, lead generation, lead campaign, smart match lander, intelligent lander, a

Gene therapy restores hearing in deaf mice, down to a whisper: Improved delivery vector better penetrates the inner ear, also restores balance in a mouse model of Usher syndrome — ScienceDaily stat : sciencedaily

as informed in “Outer hair cells amplify sound, allowing inner hair cells to send a stronger signal to the brain.
“Progress in gene therapy for blindness is much further along than for hearing, and I believe our studies take an important step toward unlocking a future of hearing gene therapy,” says Vandenberghe, also an assistant professor of ophthalmology at Harvard Medical School.
This study’s three Harvard Medical School senior investigators were Jeffrey R. Holt PhD, of Boston Children’s Hospital; Konstantina Stankovic, MD, PhD, of Mass.
While previous vectors have only been able to penetrate the cochlea’s inner hair cells, the first Nature Biotechnology study showed that a new synthetic vector, Anc80, safely transferred genes to the hard-to-reach outer hair cells when introduced into the cochlea (see images).
Although these studies did not test for vision restoration, gene therapy in the eye is already starting to be done for other disorders.

Gene therapy restores hearing in deaf mice, down to a whisper: Improved delivery vector better penetrates the inner ear, also restores balance in a mouse model of Usher syndrome -- ScienceDaily

As it stated in Outer hair cells amplify sound, allowing inner hair cells to send a stronger signal to the brain.
Dr Luk Vandenberghe, another member of the team from Harvard Medical School, who helped create the Anc80 virus, said: ‘Progress in gene therapy for blindness is much further along than for hearing and I believe our studies take an important step toward unlocking a future of hearing gene therapy.’
But a new form of gene therapy could restore hearing in people with this condition.
Although the research did not test for vision restoration, gene therapy for eye disorders is already at an advanced state of development.
The gene therapy virus, known as Anc80, was able to ‘infect’ a hard-to-reach subset of the cells called ‘outer hair cells’ that effectively act as a pre-amplifier.
Gene therapy restores hearing in deaf mice

As it stated in An improved gene Therapy vector restores hearing and balance in genetically deaf mice, according to Boston’s Children’s Hospital researchers.
“Outer hair cells amplify sound, allowing inner hair cells to send a stronger signal to the brain.
They also aim to test gene Therapy in larger animals and plan to develop treatments for other types of genetic hearing loss.
The trio developed a new synthetic vector called Anc80 in 2015 at Massachusetts Eye and Ear’s Grousbeck Gene Therapy Center.
The researchers also discovered that the gene Therapy restored balance in the mice and eliminated erratic movements.

about the details read more from here

This content may collect you by Victoria Hunter

To follow all the new news about Therapy

Check Also

picture.jpg

medicinal Marijuana For Kids by Cancer disease Broadly Supported By Doctors

As it stated in The 44% response average resulted in 288 responders who answered questions …