as mentioned in Manjurul Haque/EyeEm/GettyA new vaccine against Zika virus gives mice and monkeys immunity in tests.
Weissman’s vaccine is also more potent, giving rhesus macaques immunity to Zika virus at one-twentieth of the dose needed for other vaccines.
The vaccine is based on the inactivated virus, and just one low dose is needed.
The fifth monkey had a small amount of the virus present, possibly because it received too high a dose of the vaccine.
In their tests, the team found that mice that received the vaccine were immune at two weeks and at five months following the dose.
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Gatekeeper immune cells are fighting Zika virus with an arm tied behind their backs, scientists from Emory Vaccine Center report.
When Zika virus infects them, it shuts down interferon signaling, one route for mustering the antiviral troops.
The authors also suspect that Zika targets other immune pathways in dendritic cells in addition to interferon signaling and continue to investigate those.
All of the tested Zika viruses blocked type I interferon signaling, suggesting a highly conserved mechanism amongst Zika viruses to inhibit dendritic cell antiviral responses.
Dendritic cells are “sentinel” cells that alert the rest of the immune system when they detect viral infection.
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