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The effect of obesity on breast cancer types varies

When all the breast cancer subtypes were examined together, there was no association between BMI and recurrence or breast cancer death.
The hazard ratio (HR) per 5-kg/m2 increase was 1.05 (95% CI, 0.95–1.15) for breast cancer death, and 1.03 (95% CI, 0.92–1.13) for cancer recurrence.
The assay defines four distinct subtypes: luminal A (562 patients), luminal B (345 patients), basal-like (310 patients), and HER2-overexpressing (342 patients).
“Although prediagnosis obesity is an established risk factor for postmenopausal breast cancer, studies of obesity and breast cancer survival have produced heterogeneous results,” wrote study authors led by Elizabeth M. Cespedes Feliciano, ScD, ScM, of Kaiser Permanente Northern California in Oakland.
Over a median follow-up of 9 years, there were 378 recurrences and 544 deaths, including 312 deaths from breast cancer.

Effect of Obesity on Breast Cancer

As it stated in A study by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center found cancer cells grow more rapidly in “fatty, obese tissue,” particularly cells that cause breast cancer.
Now a study has linked being overweight and obesity to increased risks of another deadly disease, breast cancer.
“In breast cancer, we know that the cancer is embedded in very fatty tissue, because the breast is made up largely of adipose tissue.
Scientists looked at microenvironments of lean, obese and formerly obese lab mice during the study.
Tumors found in obese microenvironments were significantly larger and more prevalent than those found in lean models.

As it stated in

Obesity Makes Breast Cancer Grow Faster

They believe the study can help explain the obesity cancer link, providing evidence that elements of the fatty tissue surrounding cancer cells may help the cancer to grow.
It’s also the environment surrounding cancer cells that drives the disease, according to researchers at the University of North Carolina Lineberger Comprehensive Cancer Center.
Credit: UNC Lineberger Comprehensive Cancer CenterIt’s not just what’s inside breast cancer cells that matters.
“In breast cancer, we know that the cancer is embedded in very fatty tissue, because the breast is made up largely of adipose tissue.
She will speak on the obesity-cancer link, and the role that immune cells surrounding tumors may play in also helping to drive the disease.

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