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Zika vaccine trials transition to the second stage of testing on humans

As it stated in Scientists around the world are racing to create viable versions of a Zika vaccine.
The vaccine will not be tested in pregnant women, but it will be tested in women of child-bearing age.
The vaccine could be moved to the next phase by the end of the year if all goes according to plan.
The US$100 million trial is fully funded through this phase, but it is not yet clear whether funding is available for the next phase.
This leg of the trial will involve 90 healthy adults divided into groups who will get different doses of the vaccine.

referring to

Live-Attenuated Zika Vaccine Candidate Successful in Mice

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models.
The first live-attenuated vaccine candidate completely protects against Zika infection [news release].
Additionally, the results found that the vaccine demonstrated a promising safety profile when compared with clinically approved live-attenuated vaccines.“A successful vaccine requires a fine balance between efficacy and safety,” Pei-Yong Shi, senior author and I.H.
A single immunization dose was shown to produce strong immune responses and prevented the virus from infecting the mice.
A developmental live-attenuated Zika vaccine showed complete protection from the virus in mice after a single vaccination dose, according to new research published in Nature Medicine.The research was led by teams from the University of Texas Medical Branch (UTMB) at Galveston and Instituto Evandro Chagas at the Ministry of Health in Brazil.Researchers created the vaccine by engineering the Zika virus by deleting 1 segment of the viral genome – an approach that has been successful in the development of a dengue virus vaccine.
Zika Vaccine

referring to The only difference between the vaccine strain of Zika virus and an actual infection by Zika virus is the ‘attenuation’ of the vaccine strain – meaning that it will not cause illness.
A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models.
A new Zika vaccine may be just around the corner, with incredibly promising results recently published in Nature Medicine.
This Zika vaccine strain seems to be even better than most.
Not only that, but, the vaccine strain did not infect mosquitoes after they fed on it in spiked-blood meals.

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